Sunao Manabe, President and COO Antoine Yver MD MSc, Exec VP & Global Head R&D Oncology Chair Cancer Enterprise PLAY LIST from the beginning Opening Transforming into Oncology Forward-looking Statements Our History and the Path to Merger With Continued Focus on Discovery… Becoming a Competitive Force by Establishing Strength & Expertise in Diverse Modalities Making Progress & Realizing the 2025 Vision in Oncology Exceptional Progress & Momentum in our ADC Franchise DS-8201 | Most Recent Data DS-8201 | Strategic Collaboration with AstraZeneca DS-8201 | Strategic Collaboration … Our Intent DS ADC Technology: Platform Technology DS RD Capability @ ASCO2019 Highlights Today’s Agenda ・DS-8201 Daiichi Sankyo AstraZeneca DS-8201 Collaboration DS-8201 | HER2 mBreast Cancer Post T-DM1 Submissions Plan DS-8201 | HER2 Gastric Cancer Submission Plan DS-8201 | Remarkable Speed in Development & Manufacturing DS-8201 | Redefining HER2 in Breast Cancer & Beyond DS-8201 | HER2+ Breast & Gastric P1 Cohorts DS-8201 | April 29, 2019 Lancet Oncology Editorial DS-8201 | P1 Study Lancet Oncology Breast Cancer DS-8201 | P1 Study Lancet Oncology Gastric Cancer DS-8201 | Safety: ILD ・U3-1402 & DS-1062 Daiichi Sankyo ADC Franchise (as of June 2019) U3-1402 Phase 1 Dose Escalation and Expansion Study Baseline Characteristics of Patients Treated with U3-1402 TEAEs and DLTs in Patients Treated with U3-1402 Safety Summary of Patients Treated with U3-1402 U3-1402 Antitumor Activity Across Diverse EGFR-TKI Resistance Mechanisms U3-1402 Antitumor Activity Across Diverse EGFR-TKI Resistance Mechanisms U3-1402 Antitumor Activity Over Time U3-1402 Treatment Duration U3-1402 Patient Case U3-1402 NSCLC | What it Means for Us 2 U3-1402 & DS-1062 DS-1062 | TROP2 DXd ADC with Selective DAR4 DS-1062 | In vitro Cell Growth Inhibitory Activity DS-1062 | Anti-Tumor Activity in Xenograft Mice Models DS-1062 | Contrast with Sacituzumab Govitecan DS-1062 | TROP2 Targeted ADC Dose Escalation in Relapsed NSCLC : MTD Not Reached Safety Summary, Number of Patients with TEAEs (in 10% of patients), Regardless of Causality Objective responses emerging at >2mg/kg dose Anti-tumor Activity CT Scan Findings in Dose Escalation CT Scan Findings in Dose Escalation CT Scan Findings in Dose Escalation CT Scan Findings in Dose Escalation Dose / Effect Spider Plot (preliminary data April 12, 2019) DS-1062 NSCLC | What it Means for Us ・DS-7300 & DS-6157 DS-7300 | B7-H3 Targeted ADC to Enter Clinic in FY2019 DS-6157 | GPR20 ADC ・Regulatory Reviews Pexidartinib in TGCT Clinical Benefit ASCO 2019: Updated Efficacy in TGCT ASCO 2019: Updated Safety in TGCT (ENLIVEN and Phase 1) Pexidartinib Quizartinib ・Rest of the Portfolio AML / HEM Franchise Continues to Progress MajorR&D Pipeline in Oncology (As of June 2019) Upcoming Milestones Q&A Q&A 1 Q&A 2 Q&A 3 Q&A 4 Back Next